Drug interactions
Clonazepam + Zuranolone
Severity: Major
Clonazepam and Zuranolone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are GABA-A positive modulators and depress the CNS. Together they can increase somnolence, dizziness and impairment of driving and psychomotor performance.
What this interaction means in plain words
Clonazepam and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonazepam belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression through GABA-A receptor modulation.
What to do
Avoid the combination where possible; if needed, consider reducing the zuranolone dose and monitor for sedation. Advise patients not to drive for at least 12 hours after each zuranolone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Clonazepam with Zuranolone?
MediHelp rates the interaction as major. Clonazepam and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are GABA-A positive modulators and depress the CNS. Together they can increase somnolence, dizziness and impairment of driving and psychomotor performance.
How serious is the interaction between Clonazepam and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, consider reducing the zuranolone dose and monitor for sedation. Advise patients not to drive for at least 12 hours after each zuranolone dose.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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