Drug interactions
Clonidine + Isavuconazonium
Severity: Minor
Clonidine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, moderately inhibits CYP3A4 and P-glycoprotein, which may modestly increase clonidine concentrations. Since clonidine has multiple elimination routes, the effect is likely small but could increase bradycardia, hypotension and sedation.
What this interaction means in plain words
Clonidine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by isavuconazole may reduce clonidine clearance.
What to do
Monitor heart rate and blood pressure when starting or stopping isavuconazonium. Reduce the clonidine dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Clonidine with Isavuconazonium?
MediHelp rates the interaction as minor. Clonidine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole, the active moiety, moderately inhibits CYP3A4 and P-glycoprotein, which may modestly increase clonidine concentrations. Since clonidine has multiple elimination routes, the effect is likely small but could increase bradycardia, hypotension and sedation.
How serious is the interaction between Clonidine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping isavuconazonium. Reduce the clonidine dose if bradycardia or hypotension develops.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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