Drug interactions
Clonidine + Levobunolol
Severity: Moderate
Clonidine and Levobunolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower heart rate, and beta-blockers can worsen rebound hypertension when clonidine is withdrawn. Systemic absorption of levobunolol from eye drops can add to bradycardia and hypotension.
What this interaction means in plain words
Clonidine and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Levobunolol belongs to Miscellaneous.
Why it happens
Additive bradycardic and hypotensive effects, with unopposed alpha stimulation on clonidine withdrawal.
What to do
Monitor heart rate and blood pressure. If clonidine is stopped, taper gradually and withdraw the beta-blocker first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Levobunolol
- Digoxin + Levobunolol Moderate
- Diltiazem + Levobunolol Moderate
- Fingolimod + Levobunolol Moderate
- Levobunolol + Rivastigmine Moderate
- Levobunolol + Verapamil Moderate
Frequently asked questions
Can I take Clonidine with Levobunolol?
MediHelp rates the interaction as moderate. Clonidine and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower heart rate, and beta-blockers can worsen rebound hypertension when clonidine is withdrawn. Systemic absorption of levobunolol from eye drops can add to bradycardia and hypotension.
How serious is the interaction between Clonidine and Levobunolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure. If clonidine is stopped, taper gradually and withdraw the beta-blocker first.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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