Drug interactions
Digoxin + Levobunolol
Severity: Moderate
Digoxin and Levobunolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levobunolol is an ophthalmic beta-blocker with some systemic absorption. In susceptible patients it may add to digoxin's slowing of AV nodal conduction and cause bradycardia. The risk is greatest in older patients and those with existing conduction disease.
What this interaction means in plain words
Digoxin and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Levobunolol belongs to Miscellaneous.
Why it happens
Additive negative chronotropic and dromotropic effects from beta-blockade and digoxin's vagotonic action.
What to do
Monitor pulse and ECG in patients with conduction disease or bradycardia; consider a non-beta-blocker glaucoma agent if heart rate falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Levobunolol
- Clonidine + Levobunolol Moderate
- Diltiazem + Levobunolol Moderate
- Fingolimod + Levobunolol Moderate
- Levobunolol + Rivastigmine Moderate
- Levobunolol + Verapamil Moderate
Frequently asked questions
Can I take Digoxin with Levobunolol?
MediHelp rates the interaction as moderate. Digoxin and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levobunolol is an ophthalmic beta-blocker with some systemic absorption. In susceptible patients it may add to digoxin's slowing of AV nodal conduction and cause bradycardia. The risk is greatest in older patients and those with existing conduction disease.
How serious is the interaction between Digoxin and Levobunolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and ECG in patients with conduction disease or bradycardia; consider a non-beta-blocker glaucoma agent if heart rate falls.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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