Drug interactions
Diltiazem + Levobunolol
Severity: Moderate
Diltiazem and Levobunolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levobunolol is an ophthalmic beta-blocker with some systemic absorption. Together with diltiazem it may add to bradycardia, AV block and hypotension, especially in older patients or those with conduction disease.
What this interaction means in plain words
Diltiazem and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Levobunolol belongs to Miscellaneous.
Why it happens
Additive negative chronotropic and dromotropic effects at the sinoatrial and AV nodes.
What to do
Monitor heart rate, ECG and blood pressure when starting or adjusting either drug. Consider a non-beta-blocker glaucoma agent in patients with conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Levobunolol
- Clonidine + Levobunolol Moderate
- Digoxin + Levobunolol Moderate
- Fingolimod + Levobunolol Moderate
- Levobunolol + Rivastigmine Moderate
- Levobunolol + Verapamil Moderate
Frequently asked questions
Can I take Diltiazem with Levobunolol?
MediHelp rates the interaction as moderate. Diltiazem and Levobunolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levobunolol is an ophthalmic beta-blocker with some systemic absorption. Together with diltiazem it may add to bradycardia, AV block and hypotension, especially in older patients or those with conduction disease.
How serious is the interaction between Diltiazem and Levobunolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure when starting or adjusting either drug. Consider a non-beta-blocker glaucoma agent in patients with conduction abnormalities.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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