Drug interactions
Clonidine + Loxapine
Severity: Moderate
Clonidine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and cause sedation, so combined use may cause additive hypotension, orthostatic dizziness and drowsiness. Loxapine's alpha-1 blockade adds to clonidine's central sympatholytic effect.
What this interaction means in plain words
Clonidine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Loxapine belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative effects: central alpha-2 agonism plus antipsychotic alpha-1 adrenergic blockade and CNS depression.
What to do
Monitor blood pressure including orthostatic readings, especially when starting or increasing either drug. Lower the dose of one agent if symptomatic hypotension or oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Clonidine with Loxapine?
MediHelp rates the interaction as moderate. Clonidine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure and cause sedation, so combined use may cause additive hypotension, orthostatic dizziness and drowsiness. Loxapine's alpha-1 blockade adds to clonidine's central sympatholytic effect.
How serious is the interaction between Clonidine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings, especially when starting or increasing either drug. Lower the dose of one agent if symptomatic hypotension or oversedation occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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