Drug interactions
Clonidine + Nebivolol
Severity: Moderate
Clonidine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine reduces central sympathetic outflow and nebivolol blocks beta-1 receptors, so both can cause bradycardia and hypotension. Beta-blockers can also exaggerate rebound hypertension if clonidine is stopped abruptly.
What this interaction means in plain words
Clonidine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive reduction of heart rate and blood pressure via central sympatholysis and beta-blockade.
What to do
Monitor heart rate and blood pressure when starting or adjusting either drug. If stopping both, withdraw the beta-blocker first and then taper clonidine gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Nebivolol?
MediHelp rates the interaction as moderate. Clonidine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine reduces central sympathetic outflow and nebivolol blocks beta-1 receptors, so both can cause bradycardia and hypotension. Beta-blockers can also exaggerate rebound hypertension if clonidine is stopped abruptly.
How serious is the interaction between Clonidine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting either drug. If stopping both, withdraw the beta-blocker first and then taper clonidine gradually.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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