Drug interactions
Clonidine + Neratinib
Severity: Minor
Clonidine and Neratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib inhibits P-glycoprotein, which may raise exposure to P-gp substrates. Clonidine is only partly handled by this transporter, so any increase is likely small, but bradycardia or hypotension could be amplified.
What this interaction means in plain words
Clonidine and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Neratinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by neratinib may modestly reduce clonidine efflux and clearance.
What to do
Monitor heart rate and blood pressure after starting neratinib. Lower the clonidine dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Clonidine with Neratinib?
MediHelp rates the interaction as minor. Clonidine and Neratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Neratinib inhibits P-glycoprotein, which may raise exposure to P-gp substrates. Clonidine is only partly handled by this transporter, so any increase is likely small, but bradycardia or hypotension could be amplified.
How serious is the interaction between Clonidine and Neratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting neratinib. Lower the clonidine dose if bradycardia or hypotension occurs.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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