Drug interactions
Amobarbital + Neratinib
Severity: Major
Amobarbital and Neratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is expected to substantially lower neratinib exposure by inducing CYP3A4, which may reduce efficacy in HER2-positive breast cancer.
What this interaction means in plain words
Amobarbital and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Neratinib belongs to Oncology.
Why it happens
CYP3A4 induction increases neratinib clearance.
What to do
Avoid concurrent use with strong or moderate CYP3A4 inducers. Choose an alternative to amobarbital.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
- Cimetidine + Neratinib Major
Frequently asked questions
Can I take Amobarbital with Neratinib?
MediHelp rates the interaction as major. Amobarbital and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is expected to substantially lower neratinib exposure by inducing CYP3A4, which may reduce efficacy in HER2-positive breast cancer.
How serious is the interaction between Amobarbital and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use with strong or moderate CYP3A4 inducers. Choose an alternative to amobarbital.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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