Drug interactions
Bosentan + Neratinib
Severity: Major
Bosentan and Neratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib is cleared mainly by CYP3A4, and induction by bosentan can reduce its plasma concentrations. This may diminish its efficacy in breast cancer treatment.
What this interaction means in plain words
Bosentan and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Neratinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing neratinib clearance.
What to do
Avoid coadministration and consider an alternative to bosentan. If unavoidable, monitor oncologic response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Carbamazepine + Neratinib Major
- Cimetidine + Neratinib Major
Frequently asked questions
Can I take Bosentan with Neratinib?
MediHelp rates the interaction as major. Bosentan and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Neratinib is cleared mainly by CYP3A4, and induction by bosentan can reduce its plasma concentrations. This may diminish its efficacy in breast cancer treatment.
How serious is the interaction between Bosentan and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and consider an alternative to bosentan. If unavoidable, monitor oncologic response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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