Drug interactions
Clonidine + Oxymorphone
Severity: Moderate
Clonidine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine can cause sedation, bradycardia and hypotension, and these effects add to opioid-induced CNS and respiratory depression. The combination can produce profound sedation and hemodynamic instability, especially with higher doses or neuraxial use.
What this interaction means in plain words
Clonidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension from central alpha-2 agonism combined with mu-opioid effects.
What to do
Start with low doses and titrate carefully while monitoring blood pressure, heart rate and sedation. Reduce the dose of one or both agents if excessive sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Oxymorphone?
MediHelp rates the interaction as moderate. Clonidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine can cause sedation, bradycardia and hypotension, and these effects add to opioid-induced CNS and respiratory depression. The combination can produce profound sedation and hemodynamic instability, especially with higher doses or neuraxial use.
How serious is the interaction between Clonidine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate carefully while monitoring blood pressure, heart rate and sedation. Reduce the dose of one or both agents if excessive sedation or hypotension occurs.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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