Drug interactions
Clonidine + Quetiapine
Severity: Moderate
Clonidine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is strongly sedating and causes alpha-1 mediated orthostatic hypotension, which can add to clonidine's hypotensive and sedative effects. This raises the risk of dizziness, syncope and falls.
What this interaction means in plain words
Clonidine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative effects from central alpha-2 agonism and quetiapine's alpha-1 blockade and antihistaminic activity.
What to do
Monitor orthostatic blood pressure and sedation, particularly during dose titration. Lower the dose of one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Clonidine with Quetiapine?
MediHelp rates the interaction as moderate. Clonidine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is strongly sedating and causes alpha-1 mediated orthostatic hypotension, which can add to clonidine's hypotensive and sedative effects. This raises the risk of dizziness, syncope and falls.
How serious is the interaction between Clonidine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and sedation, particularly during dose titration. Lower the dose of one agent if symptoms occur.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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