Drug interactions
Clonidine + Ziprasidone
Severity: Moderate
Clonidine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone can cause orthostatic hypotension and sedation, adding to clonidine's effects. Clonidine-related bradycardia may also be unfavorable given ziprasidone's QT-prolonging effect.
What this interaction means in plain words
Clonidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonidine belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive and sedative effects; bradycardia may add to QT-related arrhythmia risk.
What to do
Monitor blood pressure and heart rate and consider an ECG in patients with cardiac risk. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Clonidine with Ziprasidone?
MediHelp rates the interaction as moderate. Clonidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone can cause orthostatic hypotension and sedation, adding to clonidine's effects. Clonidine-related bradycardia may also be unfavorable given ziprasidone's QT-prolonging effect.
How serious is the interaction between Clonidine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and consider an ECG in patients with cardiac risk. Keep potassium and magnesium within normal range.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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