Drug interactions
Clopidogrel + Deferasirox
Severity: Moderate
Clopidogrel and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastrointestinal ulceration and hemorrhage, and clopidogrel increases the likelihood of bleeding from such lesions. The combination raises the risk of serious GI bleeding.
What this interaction means in plain words
Clopidogrel and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effect: mucosal injury from deferasirox plus platelet inhibition by clopidogrel.
What to do
Monitor for GI bleeding signs and hemoglobin, and consider a proton pump inhibitor that has minimal CYP2C19 inhibition such as pantoprazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Deferasirox
Frequently asked questions
Can I take Clopidogrel with Deferasirox?
MediHelp rates the interaction as moderate. Clopidogrel and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause gastrointestinal ulceration and hemorrhage, and clopidogrel increases the likelihood of bleeding from such lesions. The combination raises the risk of serious GI bleeding.
How serious is the interaction between Clopidogrel and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and hemoglobin, and consider a proton pump inhibitor that has minimal CYP2C19 inhibition such as pantoprazole.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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