Drug interactions
Clopidogrel + Ethotoin
Severity: Minor
Clopidogrel and Ethotoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is a hydantoin anticonvulsant, and related hydantoins such as phenytoin are metabolized partly by CYP2C19, which clopidogrel can inhibit. Raised ethotoin levels are plausible but not well documented, and the effect is probably small.
What this interaction means in plain words
Clopidogrel and Ethotoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2C-mediated metabolism of ethotoin by clopidogrel, extrapolated from related hydantoins.
What to do
Monitor for signs of ethotoin toxicity such as dizziness, ataxia or nystagmus when clopidogrel is started, and adjust the dose by clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Ethotoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Ethotoin?
MediHelp rates the interaction as minor. Clopidogrel and Ethotoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethotoin is a hydantoin anticonvulsant, and related hydantoins such as phenytoin are metabolized partly by CYP2C19, which clopidogrel can inhibit. Raised ethotoin levels are plausible but not well documented, and the effect is probably small.
How serious is the interaction between Clopidogrel and Ethotoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of ethotoin toxicity such as dizziness, ataxia or nystagmus when clopidogrel is started, and adjust the dose by clinical response.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
