Drug interactions
Clopidogrel + Fenoprofen
Severity: Major
Clopidogrel and Fenoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair platelet function, and NSAIDs also damage the gastric mucosa. Combined use increases the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Clopidogrel and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive platelet inhibition (P2Y12 blockade plus reversible COX-1 inhibition) with NSAID mucosal injury.
What to do
Avoid regular NSAID use with clopidogrel, preferring paracetamol where possible. If needed, use the shortest course and add gastroprotection with a proton pump inhibitor such as pantoprazole.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Fenoprofen?
MediHelp rates the interaction as major. Clopidogrel and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs impair platelet function, and NSAIDs also damage the gastric mucosa. Combined use increases the risk of gastrointestinal and other bleeding.
How serious is the interaction between Clopidogrel and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with clopidogrel, preferring paracetamol where possible. If needed, use the shortest course and add gastroprotection with a proton pump inhibitor such as pantoprazole.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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