Drug interactions
Clopidogrel + Hydrocortisone
Severity: Minor
Clopidogrel and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer, which could theoretically increase conversion of clopidogrel to its active metabolite. No clinically meaningful change in antiplatelet effect is established. Corticosteroids may separately add to gastrointestinal bleeding risk.
What this interaction means in plain words
Clopidogrel and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction; steroids also add to GI mucosal injury risk.
What to do
No dose adjustment needed; watch for gastrointestinal bleeding and consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Hydrocortisone?
MediHelp rates the interaction as minor. Clopidogrel and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer, which could theoretically increase conversion of clopidogrel to its active metabolite. No clinically meaningful change in antiplatelet effect is established. Corticosteroids may separately add to gastrointestinal bleeding risk.
How serious is the interaction between Clopidogrel and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; watch for gastrointestinal bleeding and consider gastroprotection in high-risk patients.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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