Drug interactions
Clopidogrel + Inotersen
Severity: Major
Clopidogrel and Inotersen: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotersen can cause thrombocytopenia, and clopidogrel inhibits platelet function. Combined use raises the risk of serious bleeding.
What this interaction means in plain words
Clopidogrel and Inotersen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Inotersen belongs to Miscellaneous.
Why it happens
Additive bleeding risk from drug-induced thrombocytopenia plus antiplatelet effect.
What to do
Monitor platelet counts regularly as required for inotersen and assess bleeding signs; reassess the need for clopidogrel if platelets fall.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Inotersen
- Acetylsalicylic acid + Inotersen Major
- Apixaban + Inotersen Major
- Inotersen + Rivaroxaban Major
- Inotersen + Warfarin Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Inotersen?
MediHelp rates the interaction as major. Clopidogrel and Inotersen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotersen can cause thrombocytopenia, and clopidogrel inhibits platelet function. Combined use raises the risk of serious bleeding.
How serious is the interaction between Clopidogrel and Inotersen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly as required for inotersen and assess bleeding signs; reassess the need for clopidogrel if platelets fall.
What other medicines interact with Inotersen?
MediHelp also lists interactions of Inotersen with, for example, Acetylsalicylic acid, Apixaban, Rivaroxaban. The full list is on the Inotersen page.
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