Drug interactions
Clopidogrel + Lansoprazole
Severity: Moderate
Clopidogrel and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole has weak CYP2C19 inhibition and may slightly reduce formation of clopidogrel's active metabolite. The effect is smaller than with omeprazole or esomeprazole, and clinical significance is uncertain.
What this interaction means in plain words
Clopidogrel and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2C19 reduces bioactivation of clopidogrel.
What to do
If gastroprotection is needed, prefer pantoprazole, which has less CYP2C19 effect. Avoid omeprazole and esomeprazole with clopidogrel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Lansoprazole?
MediHelp rates the interaction as moderate. Clopidogrel and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lansoprazole has weak CYP2C19 inhibition and may slightly reduce formation of clopidogrel's active metabolite. The effect is smaller than with omeprazole or esomeprazole, and clinical significance is uncertain.
How serious is the interaction between Clopidogrel and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If gastroprotection is needed, prefer pantoprazole, which has less CYP2C19 effect. Avoid omeprazole and esomeprazole with clopidogrel.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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