Drug interactions
Clopidogrel + Meclofenamate
Severity: Moderate
Clopidogrel and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that reduces platelet function and can injure the gastric lining. Together with clopidogrel it increases the likelihood of gastrointestinal and other bleeding.
What this interaction means in plain words
Clopidogrel and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects through COX inhibition and P2Y12 blockade, plus NSAID-related mucosal damage.
What to do
Prefer paracetamol or another non-NSAID analgesic. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding, considering gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Meclofenamate?
MediHelp rates the interaction as moderate. Clopidogrel and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that reduces platelet function and can injure the gastric lining. Together with clopidogrel it increases the likelihood of gastrointestinal and other bleeding.
How serious is the interaction between Clopidogrel and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another non-NSAID analgesic. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding, considering gastroprotection.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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