Drug interactions
Clopidogrel + Nefazodone
Severity: Moderate
Clopidogrel and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may reduce the formation of clopidogrel's active metabolite. The clinical significance is uncertain but antiplatelet efficacy could be reduced.
What this interaction means in plain words
Clopidogrel and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nefazodone may reduce bioactivation of clopidogrel.
What to do
Prefer another antidepressant that does not inhibit CYP3A4 in patients who need clopidogrel. If combined, monitor for ischemic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Nefazodone?
MediHelp rates the interaction as moderate. Clopidogrel and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may reduce the formation of clopidogrel's active metabolite. The clinical significance is uncertain but antiplatelet efficacy could be reduced.
How serious is the interaction between Clopidogrel and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer another antidepressant that does not inhibit CYP3A4 in patients who need clopidogrel. If combined, monitor for ischemic events.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
