Drug interactions
Clopidogrel + Rabeprazole
Severity: Minor
Clopidogrel and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel needs CYP2C19 to form its active metabolite. Rabeprazole is a weak CYP2C19 inhibitor and is metabolized mostly non-enzymatically, so it has little effect on platelet inhibition compared with omeprazole.
What this interaction means in plain words
Clopidogrel and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by rabeprazole could slightly reduce activation of clopidogrel.
What to do
Rabeprazole can be used if a PPI is needed with clopidogrel; avoid omeprazole and esomeprazole, and prefer pantoprazole where possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clopidogrel and Rabeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Rabeprazole?
MediHelp rates the interaction as minor. Clopidogrel and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel needs CYP2C19 to form its active metabolite. Rabeprazole is a weak CYP2C19 inhibitor and is metabolized mostly non-enzymatically, so it has little effect on platelet inhibition compared with omeprazole.
How serious is the interaction between Clopidogrel and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Rabeprazole can be used if a PPI is needed with clopidogrel; avoid omeprazole and esomeprazole, and prefer pantoprazole where possible.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
