Drug interactions
Clopidogrel + Salicylates
Severity: Moderate
Clopidogrel and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates have some effect on platelets and the gastric mucosa, so taking them with clopidogrel may add to bleeding risk. The effect depends on the specific salicylate and dose, and is usually less than with aspirin.
What this interaction means in plain words
Clopidogrel and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function and mucosal integrity with P2Y12 inhibition.
What to do
Monitor for bleeding, particularly gastrointestinal, and avoid unnecessary co-use. Consider gastroprotection if the combination continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Salicylates?
MediHelp rates the interaction as moderate. Clopidogrel and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates have some effect on platelets and the gastric mucosa, so taking them with clopidogrel may add to bleeding risk. The effect depends on the specific salicylate and dose, and is usually less than with aspirin.
How serious is the interaction between Clopidogrel and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, particularly gastrointestinal, and avoid unnecessary co-use. Consider gastroprotection if the combination continues.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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