Drug interactions
Clopidogrel + Salsalate
Severity: Moderate
Clopidogrel and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which can affect platelet function and the gastric mucosa. Combined with clopidogrel, it may add to bleeding risk, although salsalate has a weaker antiplatelet effect than aspirin.
What this interaction means in plain words
Clopidogrel and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects and mucosal irritation from salicylate with P2Y12 inhibition.
What to do
Monitor for bleeding, especially gastrointestinal. Consider an alternative analgesic or gastroprotection if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Salsalate?
MediHelp rates the interaction as moderate. Clopidogrel and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid, which can affect platelet function and the gastric mucosa. Combined with clopidogrel, it may add to bleeding risk, although salsalate has a weaker antiplatelet effect than aspirin.
How serious is the interaction between Clopidogrel and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, especially gastrointestinal. Consider an alternative analgesic or gastroprotection if long-term use is needed.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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