Drug interactions
Clopidogrel + Selumetinib
Severity: Moderate
Clopidogrel and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib has been associated with hemorrhage, and its labeling advises caution with antiplatelet agents. Combined with clopidogrel the risk of bleeding may be increased.
What this interaction means in plain words
Clopidogrel and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Additive bleeding risk from antiplatelet activity of clopidogrel and the bleeding tendency associated with selumetinib; the exact mechanism for selumetinib is not well established.
What to do
Monitor patients for signs of bleeding and check blood counts. Reassess the need for both agents if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Selumetinib
Frequently asked questions
Can I take Clopidogrel with Selumetinib?
MediHelp rates the interaction as moderate. Clopidogrel and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib has been associated with hemorrhage, and its labeling advises caution with antiplatelet agents. Combined with clopidogrel the risk of bleeding may be increased.
How serious is the interaction between Clopidogrel and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for signs of bleeding and check blood counts. Reassess the need for both agents if bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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