Drug interactions
Clopidogrel + Venlafaxine
Severity: Moderate
Clopidogrel and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and aggregation, which adds to clopidogrel's antiplatelet effect. This raises the risk of bleeding, particularly gastrointestinal.
What this interaction means in plain words
Clopidogrel and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on platelet function from SNRI-induced platelet serotonin depletion plus P2Y12 inhibition.
What to do
Monitor for bleeding and consider gastroprotection in higher-risk patients. Reassess the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Clopidogrel with Venlafaxine?
MediHelp rates the interaction as moderate. Clopidogrel and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and aggregation, which adds to clopidogrel's antiplatelet effect. This raises the risk of bleeding, particularly gastrointestinal.
How serious is the interaction between Clopidogrel and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in higher-risk patients. Reassess the combination if bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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