Drug interactions
Clotrimazole + Infigratinib
Severity: Moderate
Clotrimazole and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clotrimazole could raise infigratinib exposure and increase toxicities such as hyperphosphatemia, ocular effects and fatigue. Clinical significance depends on how much clotrimazole is systemically absorbed.
What this interaction means in plain words
Clotrimazole and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clotrimazole inhibits CYP3A4, which metabolizes infigratinib.
What to do
Prefer topical clotrimazole or a non-inhibiting antifungal. If used systemically, monitor phosphate and for adverse effects and reduce the infigratinib dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Infigratinib?
MediHelp rates the interaction as moderate. Clotrimazole and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole could raise infigratinib exposure and increase toxicities such as hyperphosphatemia, ocular effects and fatigue. Clinical significance depends on how much clotrimazole is systemically absorbed.
How serious is the interaction between Clotrimazole and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical clotrimazole or a non-inhibiting antifungal. If used systemically, monitor phosphate and for adverse effects and reduce the infigratinib dose if needed.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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