Drug interactions
Clozapine + Cyclosporin
Severity: Moderate
Clozapine and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase clozapine concentrations, increasing the risk of sedation, seizures, hypotension and other dose-related toxicity. Both drugs can also cause bone marrow or other adverse effects that complicate assessment.
What this interaction means in plain words
Clozapine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, which contributes to clozapine metabolism.
What to do
Monitor for sedation, seizures and hypotension, and consider checking clozapine levels and reducing the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Cyclosporin?
MediHelp rates the interaction as moderate. Clozapine and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase clozapine concentrations, increasing the risk of sedation, seizures, hypotension and other dose-related toxicity. Both drugs can also cause bone marrow or other adverse effects that complicate assessment.
How serious is the interaction between Clozapine and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, seizures and hypotension, and consider checking clozapine levels and reducing the dose if toxicity occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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