Drug interactions
Clozapine + Cyproheptadine
Severity: Moderate
Clozapine and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating and anticholinergic, so combined use can cause pronounced drowsiness and worsen constipation, which is a serious concern with clozapine because of the risk of bowel obstruction. Hypotension and confusion may also occur.
What this interaction means in plain words
Clozapine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Cyproheptadine belongs to Respiratory.
Why it happens
Additive H1 antagonism, CNS depression and anticholinergic effects.
What to do
Monitor for sedation, orthostatic hypotension and constipation, and treat bowel symptoms promptly. Avoid the combination when other options exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Cyproheptadine?
MediHelp rates the interaction as moderate. Clozapine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating and anticholinergic, so combined use can cause pronounced drowsiness and worsen constipation, which is a serious concern with clozapine because of the risk of bowel obstruction. Hypotension and confusion may also occur.
How serious is the interaction between Clozapine and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and constipation, and treat bowel symptoms promptly. Avoid the combination when other options exist.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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