Drug interactions
Clozapine + Entrectinib
Severity: Major
Clozapine and Entrectinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and clozapine can also affect cardiac repolarisation. Using them together may raise the risk of torsades de pointes. Entrectinib is also associated with CNS effects that may add to the sedation caused by clozapine.
What this interaction means in plain words
Clozapine and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Avoid the combination if possible. If both are required, obtain ECGs and electrolytes at baseline and during treatment, and follow the entrectinib label for dose reduction or interruption if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Clozapine Viatris 100 mg Orodispersible Tablets - SmPC sections 4.3/4.5 (class statement: medicines known to increase QTc interval; "caution should be exercised when clozapine is prescribed with medicines known to increase QTc interval, or causing electrolyte imbalance.") — electronic medicines compendium (UK SmPC)
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Clozapine with Entrectinib?
MediHelp rates the interaction as major. Clozapine and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval, and clozapine can also affect cardiac repolarisation. Using them together may raise the risk of torsades de pointes. Entrectinib is also associated with CNS effects that may add to the sedation caused by clozapine.
How serious is the interaction between Clozapine and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are required, obtain ECGs and electrolytes at baseline and during treatment, and follow the entrectinib label for dose reduction or interruption if the QTc becomes prolonged.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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