Drug interactions
Clozapine + Frovatriptan
Severity: Moderate
Clozapine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with a serotonergically active antipsychotic carries a theoretical risk of serotonin syndrome, and antipsychotic dopamine blockade is linked to neuroleptic malignant syndrome. Reported cases are rare.
What this interaction means in plain words
Clozapine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is largely theoretical.
What to do
Advise the patient to report agitation, tremor, fever or muscle rigidity. Monitor for serotonin syndrome and neuroleptic malignant syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Frovatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Clozapine with Frovatriptan?
MediHelp rates the interaction as moderate. Clozapine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with a serotonergically active antipsychotic carries a theoretical risk of serotonin syndrome, and antipsychotic dopamine blockade is linked to neuroleptic malignant syndrome. Reported cases are rare.
How serious is the interaction between Clozapine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report agitation, tremor, fever or muscle rigidity. Monitor for serotonin syndrome and neuroleptic malignant syndrome.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
