Drug interactions
Clozapine + Gliclazide
Severity: Moderate
Clozapine and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with hyperglycemia, new-onset diabetes and diabetic ketoacidosis, and can oppose gliclazide's effect. Glycemic control may deteriorate substantially.
What this interaction means in plain words
Clozapine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Gliclazide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism due to clozapine-induced insulin resistance and impaired beta-cell function.
What to do
Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as required. Educate the patient about hyperglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Gliclazide?
MediHelp rates the interaction as moderate. Clozapine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with hyperglycemia, new-onset diabetes and diabetic ketoacidosis, and can oppose gliclazide's effect. Glycemic control may deteriorate substantially.
How serious is the interaction between Clozapine and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as required. Educate the patient about hyperglycemia symptoms.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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