Drug interactions
Clozapine + Glipizide-metformin
Severity: Moderate
Clozapine and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine commonly causes weight gain, insulin resistance and hyperglycemia, and can precipitate diabetes or ketoacidosis. This can reduce the effectiveness of glipizide and metformin.
What this interaction means in plain words
Clozapine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Clozapine causes metabolic effects including insulin resistance and impaired beta-cell function, opposing the glucose-lowering drugs.
What to do
Monitor fasting glucose and HbA1c regularly and titrate antidiabetic therapy as needed. Review glucose control when clozapine is started, changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Glipizide-metformin?
MediHelp rates the interaction as moderate. Clozapine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine commonly causes weight gain, insulin resistance and hyperglycemia, and can precipitate diabetes or ketoacidosis. This can reduce the effectiveness of glipizide and metformin.
How serious is the interaction between Clozapine and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and titrate antidiabetic therapy as needed. Review glucose control when clozapine is started, changed or stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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