Drug interactions
Clozapine + Glyburide-metformin
Severity: Moderate
Clozapine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can counteract the glucose-lowering effect of glyburide-metformin and may require stronger diabetes treatment.
What this interaction means in plain words
Clozapine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Clozapine causes metabolic effects including insulin resistance and impaired insulin secretion that oppose the antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during clozapine therapy, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Clozapine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can counteract the glucose-lowering effect of glyburide-metformin and may require stronger diabetes treatment.
How serious is the interaction between Clozapine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during clozapine therapy, and adjust antidiabetic therapy as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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