Drug interactions
Clozapine + Insulin glargine-lixisenatide
Severity: Moderate
Clozapine and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. It can substantially undermine glycemic control and raise insulin requirements. Severe hyperglycemia and ketoacidosis have been reported.
What this interaction means in plain words
Clozapine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Pharmacodynamic opposition; clozapine-induced insulin resistance and impaired insulin secretion.
What to do
Monitor glucose and HbA1c regularly and titrate the antidiabetic doses. Reassess the doses if clozapine is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Clozapine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. It can substantially undermine glycemic control and raise insulin requirements. Severe hyperglycemia and ketoacidosis have been reported.
How serious is the interaction between Clozapine and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly and titrate the antidiabetic doses. Reassess the doses if clozapine is changed or stopped.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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