Drug interactions
Clozapine + Isoflurane
Severity: Moderate
Clozapine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and volatile anesthetics may add to clozapine's hypotensive and sedative effects. Perioperative arrhythmia risk may rise.
What this interaction means in plain words
Clozapine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive hypotensive and CNS depressant effects.
What to do
Monitor ECG and blood pressure during anesthesia and maintain normal electrolytes. Tell the anesthesia team that the patient takes clozapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Clozapine with Isoflurane?
MediHelp rates the interaction as moderate. Clozapine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and volatile anesthetics may add to clozapine's hypotensive and sedative effects. Perioperative arrhythmia risk may rise.
How serious is the interaction between Clozapine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure during anesthesia and maintain normal electrolytes. Tell the anesthesia team that the patient takes clozapine.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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