Drug interactions
Clozapine + Lumateperone
Severity: Moderate
Clozapine and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, so using them together can increase somnolence, orthostatic hypotension and motor instability, with a risk of falls. Dopamine and serotonin receptor blockade is additive, and combined antipsychotic therapy is rarely supported by evidence.
What this interaction means in plain words
Clozapine and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Additive dopaminergic, serotonergic and adrenergic receptor blockade and CNS depression.
What to do
Assess fall risk and monitor blood pressure and sedation when starting or adjusting either drug. Reassess the need for dual antipsychotic therapy periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Clozapine with Lumateperone?
MediHelp rates the interaction as moderate. Clozapine and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics, so using them together can increase somnolence, orthostatic hypotension and motor instability, with a risk of falls. Dopamine and serotonin receptor blockade is additive, and combined antipsychotic therapy is rarely supported by evidence.
How serious is the interaction between Clozapine and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess fall risk and monitor blood pressure and sedation when starting or adjusting either drug. Reassess the need for dual antipsychotic therapy periodically.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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