Drug interactions
Clozapine + Mavacamten
Severity: Moderate
Clozapine and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and clozapine's inhibitory effect on CYP2C19 is not well established. Any increase in mavacamten exposure is uncertain, but excess exposure can reduce ejection fraction and cause heart failure.
What this interaction means in plain words
Clozapine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP2C19 inhibition reducing mavacamten clearance, not firmly established for clozapine.
What to do
Monitor left ventricular ejection fraction and clinical status per mavacamten labeling when starting or changing clozapine. Adjust mavacamten dose if echocardiographic findings or symptoms change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Clozapine with Mavacamten?
MediHelp rates the interaction as moderate. Clozapine and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and clozapine's inhibitory effect on CYP2C19 is not well established. Any increase in mavacamten exposure is uncertain, but excess exposure can reduce ejection fraction and cause heart failure.
How serious is the interaction between Clozapine and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical status per mavacamten labeling when starting or changing clozapine. Adjust mavacamten dose if echocardiographic findings or symptoms change.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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