Drug interactions
Clozapine + Metformin-repaglinide
Severity: Moderate
Clozapine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. It can therefore undermine glycemic control in patients taking metformin and repaglinide.
What this interaction means in plain words
Clozapine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through clozapine-induced insulin resistance and metabolic disturbance.
What to do
Monitor glucose and HbA1c regularly, and intensify or adjust antidiabetic therapy as required. Metformin is often used to counter clozapine-related weight gain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Clozapine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and new-onset diabetes. It can therefore undermine glycemic control in patients taking metformin and repaglinide.
How serious is the interaction between Clozapine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly, and intensify or adjust antidiabetic therapy as required. Metformin is often used to counter clozapine-related weight gain.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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