Drug interactions
Clozapine + Nateglinide
Severity: Moderate
Clozapine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine may raise blood glucose and promote insulin resistance, weakening the effect of nateglinide. Patients may have worse glycemic control and need regimen changes.
What this interaction means in plain words
Clozapine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Clozapine-induced insulin resistance and metabolic effects antagonize nateglinide's action.
What to do
Monitor glucose and HbA1c more often and adjust antidiabetic therapy. Watch for hypoglycemia if clozapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Clozapine with Nateglinide?
MediHelp rates the interaction as moderate. Clozapine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine may raise blood glucose and promote insulin resistance, weakening the effect of nateglinide. Patients may have worse glycemic control and need regimen changes.
How serious is the interaction between Clozapine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c more often and adjust antidiabetic therapy. Watch for hypoglycemia if clozapine is stopped.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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