Drug interactions
Clozapine + Oxcarbazepine
Severity: Moderate
Clozapine and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower clozapine concentrations modestly through enzyme induction, potentially reducing efficacy. Both drugs can also cause hematologic effects, and oxcarbazepine can cause hyponatremia.
What this interaction means in plain words
Clozapine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 and possibly UGT enzymes by oxcarbazepine, increasing clozapine clearance.
What to do
Monitor clinical response, consider clozapine plasma levels, and adjust the dose if needed. Monitor blood counts and sodium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Clozapine with Oxcarbazepine?
MediHelp rates the interaction as moderate. Clozapine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower clozapine concentrations modestly through enzyme induction, potentially reducing efficacy. Both drugs can also cause hematologic effects, and oxcarbazepine can cause hyponatremia.
How serious is the interaction between Clozapine and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, consider clozapine plasma levels, and adjust the dose if needed. Monitor blood counts and sodium.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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