Drug interactions
Clozapine + Safinamide
Severity: Moderate
Clozapine and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine blocks dopamine receptors and could reduce the benefit of safinamide in Parkinson disease, although clozapine causes less motor worsening than other antipsychotics. Safinamide, an MAO-B inhibitor, carries its own interaction concerns with some CNS-active drugs.
What this interaction means in plain words
Clozapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition between a dopamine receptor antagonist and a dopamine-enhancing MAO-B inhibitor.
What to do
Monitor motor symptoms and psychosis, and adjust the Parkinson therapy if control worsens. Clozapine is usually the preferred antipsychotic in Parkinson disease, so keep the dose as low as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Clozapine with Safinamide?
MediHelp rates the interaction as moderate. Clozapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine blocks dopamine receptors and could reduce the benefit of safinamide in Parkinson disease, although clozapine causes less motor worsening than other antipsychotics. Safinamide, an MAO-B inhibitor, carries its own interaction concerns with some CNS-active drugs.
How serious is the interaction between Clozapine and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and psychosis, and adjust the Parkinson therapy if control worsens. Clozapine is usually the preferred antipsychotic in Parkinson disease, so keep the dose as low as possible.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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