Drug interactions
Clozapine + Salbutamol
Severity: Moderate
Clozapine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause tachycardia, and clozapine additionally carries risks of myocarditis and orthostatic hypotension. Systemic or high-dose salbutamol may increase the risk of arrhythmia in patients on clozapine, especially with hypokalemia.
What this interaction means in plain words
Clozapine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation and tachycardic effects; beta-2 agonist-induced hypokalemia can further raise arrhythmia risk.
What to do
Monitor heart rate, ECG and serum potassium when salbutamol is used at high or nebulized doses in patients on clozapine. Correct electrolyte disturbances and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Salbutamol?
MediHelp rates the interaction as moderate. Clozapine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause tachycardia, and clozapine additionally carries risks of myocarditis and orthostatic hypotension. Systemic or high-dose salbutamol may increase the risk of arrhythmia in patients on clozapine, especially with hypokalemia.
How serious is the interaction between Clozapine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and serum potassium when salbutamol is used at high or nebulized doses in patients on clozapine. Correct electrolyte disturbances and avoid other QT-prolonging drugs where possible.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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