Drug interactions
Clozapine + Salmeterol
Severity: Moderate
Clozapine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and clozapine can also cause tachycardia and orthostatic changes, while salmeterol adds beta-agonist cardiac stimulation. Together they may increase the risk of arrhythmia, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Clozapine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation and cardiac stimulation.
What to do
Monitor ECG and potassium in patients with cardiac risk factors and watch for palpitations or syncope. Correct hypokalemia or hypomagnesemia before and during use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Salmeterol?
MediHelp rates the interaction as moderate. Clozapine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and clozapine can also cause tachycardia and orthostatic changes, while salmeterol adds beta-agonist cardiac stimulation. Together they may increase the risk of arrhythmia, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Clozapine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac risk factors and watch for palpitations or syncope. Correct hypokalemia or hypomagnesemia before and during use.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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