Drug interactions
Clozapine + Suvorexant
Severity: Moderate
Clozapine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is not an established inhibitor of suvorexant metabolism, since suvorexant is cleared mainly by CYP3A4. The main concern is additive sedation and next-day impairment when both are used.
What this interaction means in plain words
Clozapine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression; no established pharmacokinetic inhibition of suvorexant by clozapine.
What to do
Use the lowest effective suvorexant dose and warn the patient about daytime drowsiness and impaired driving. Monitor sedation and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Clozapine with Suvorexant?
MediHelp rates the interaction as moderate. Clozapine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is not an established inhibitor of suvorexant metabolism, since suvorexant is cleared mainly by CYP3A4. The main concern is additive sedation and next-day impairment when both are used.
How serious is the interaction between Clozapine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and warn the patient about daytime drowsiness and impaired driving. Monitor sedation and orthostatic symptoms.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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