Drug interactions
Clozapine + Telavancin
Severity: Moderate
Clozapine and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong QTc and has been linked to myocarditis and arrhythmias, and telavancin may add to QT prolongation. The combination may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Clozapine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation.
What to do
Check baseline and follow-up ECGs and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Telavancin?
MediHelp rates the interaction as moderate. Clozapine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can prolong QTc and has been linked to myocarditis and arrhythmias, and telavancin may add to QT prolongation. The combination may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Clozapine and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and follow-up ECGs and correct electrolyte abnormalities. Consider an alternative antibiotic in patients with cardiac disease.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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