Drug interactions
Clozapine + Zuranolone
Severity: Moderate
Clozapine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes sedation and impaired psychomotor performance, and clozapine is also strongly sedating. Taken together they can produce excessive somnolence, impaired driving ability and CNS depression.
What this interaction means in plain words
Clozapine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with zuranolone enhancing GABA-A receptor activity and clozapine acting as a sedating antipsychotic.
What to do
Counsel patients to avoid driving and hazardous activities, and consider reducing the zuranolone dose if sedation is excessive. Monitor for oversedation, especially at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Clozapine with Zuranolone?
MediHelp rates the interaction as moderate. Clozapine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes sedation and impaired psychomotor performance, and clozapine is also strongly sedating. Taken together they can produce excessive somnolence, impaired driving ability and CNS depression.
How serious is the interaction between Clozapine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous activities, and consider reducing the zuranolone dose if sedation is excessive. Monitor for oversedation, especially at initiation.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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