Drug interactions
Cobicistat + Fluticasone furoate
Severity: Major
Cobicistat and Fluticasone furoate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A inhibitor and raises fluticasone exposure. Cases of Cushing syndrome and adrenal suppression are described with boosted antiretrovirals and fluticasone.
What this interaction means in plain words
Cobicistat and Fluticasone furoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4, markedly reducing fluticasone clearance.
What to do
Avoid long-term coadministration and switch to beclomethasone or another non-CYP3A-dependent corticosteroid. If unavoidable, monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Fluticasone furoate?
MediHelp rates the interaction as major. Cobicistat and Fluticasone furoate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a potent CYP3A inhibitor and raises fluticasone exposure. Cases of Cushing syndrome and adrenal suppression are described with boosted antiretrovirals and fluticasone.
How serious is the interaction between Cobicistat and Fluticasone furoate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration and switch to beclomethasone or another non-CYP3A-dependent corticosteroid. If unavoidable, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Cobicistat?
MediHelp also lists interactions of Cobicistat with, for example, Alfuzosin, Apalutamide, Colchicine. The full list is on the Cobicistat page.
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