Drug interactions
Cobicistat + Colchicine
Severity: Contraindicated
Cobicistat and Colchicine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
What this interaction means in plain words
Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Colchicine belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces colchicine metabolism and efflux.
What to do
Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir / ritonavir Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Cobicistat + Ergotamine Contraindicated
Frequently asked questions
Can I take Cobicistat with Colchicine?
MediHelp rates the interaction as contraindicated. Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
How serious is the interaction between Cobicistat and Colchicine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.
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