Drug interactions
Cobicistat + Eletriptan
Severity: Contraindicated
Cobicistat and Eletriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of eletriptan, increasing its plasma concentrations.
What to do
Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
- Darunavir + Eletriptan Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Cobicistat + Ergotamine Contraindicated
Frequently asked questions
Can I take Cobicistat with Eletriptan?
MediHelp rates the interaction as contraindicated. Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
How serious is the interaction between Cobicistat and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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